Roy, it's been awhile since we had this conversation, but I finally found Samuel Wesley Pierce in Barbour Co. on the 1850 VA census. He is listed with parents ADAM and MARY, and several siblings. I knew he had a sister Zade, (Canzada) and the 2 of them are in this family and are the correct ages, 19, and 1. Now, my question is Where does Adam fit in? An Adam is listed in 1840 Preston Co. living next to George Pierce. Jesse Pierce is the only other Pierce in Preston Co. These are the sons of Samuel and Susannah Pierce. So did they have more sons than George, Jesse, and John? I've gone through all the Pierces listed in the 1840-1860 censuses and grouped them into their families. Adam seems to fit in as another son due to his age and locations. (He is not the Adam, son of Jesse and Elizabeth (Goff); too old. Adam's family, minus Samuel Wesley, is in Taylor Co. in 1860.
Anyway, I have more thoughts also, but think I have gone on long enough for the moment. I'm just hoping you may have some more answers for me based on what I've now found since you have such a good handle on Preston Co., WV. Thanks for any help!