U.S. States: Virginia: Warren County
Your Henry & Catherine Hoffman are listed on the 1850 Warren Co. VA census 6 Jul 1850, some of their children's marriages listed on later Warren Co. VA records.
There are Hoffman listed in birth & death records for the county of Warren, VA.
A Isaac Hoffman died 1864, record said that he was born in Shenandoah Co. VA. So you might need to look at those records. Would not appear in his old age he was living with Henry Hoffman. Might want to check the 1860 Warren Co. VA.