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Kay, since you and I last worked on the Moores together, my daughter has developed a theory, and has done much work on it. It just might affect YOUR Moore family. She has looked at all of the Moores from Scott County, and whatever few records she can find pertaining to their descendants. She has discovered there were quite a few connections to the Samuel Porter family of the Dungannon area. One of the Moores from Scott County, that she suspects might be related to our Isaac, was Sampson Moore (b. abt 1790-1795) who married Sarah Jane Porter (b. abt 1795-1800).
By old Irish naming tradition, Sampson and Sarah Jane's second son should have been named Samuel Moore. AND from the court records, we know Sampson Moore was in Pike County. This one looks promising for you to follow up on. Problem with this theory is that Samuel Porter might have had other daughters who also married Moores, and the naming pattern would also apply to their children.
As for John Noore's Branch, I suspect it belonged at one time to the John Moore who appears to have been Isaac Moore's brother. William Ramey and James Ramey owned adjacent lands, and John's wife was likely a Ramey. Her death certificate in Roane Co., WV, listed her maiden name as Raimey or Raines, with it being so sloppily scribbled as to make it debatable as to what the name was intended to be.