I checked the HISTORY OF CHESTER CO PA, by Futhey and Cope, and there is no mention of a Jesse, any spelling of Cain. I looked at the CD of area wills, with no luck....hoping to find Jesse in the will of a parent, but nothing. My wills only go to around 1830 so you might want to check the chester Co Archives and Records site, for the later wills. Perhaps you might find something there ...
Ann and John were, as you said, Quakers, who appear to have belonged to the New Garden Meeting. It contains a son John's name and his children...males were John and Robert, born respectively, 1787 and 1799 in case that's any help to 'weed' people out because of dates, etc.
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