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Samuel McKillops married Thankful Ingram.
Their daughter Lodema McKillops was born August 29, 1822 in Erie, Holland, New York (near Buffalo). She married Alonzo True James on June 1, 1844 in Quincy, Adams County, Illinois. They had seven children. She died April 5, 1876 in Hebron, Nebraska.
In the New York Census of 1830, Samuel McKeleps was listed in Holland, Erie, County; in the 1840 Census, Samuel McKelepps was listed in Quincy, Adams County.