I am not sure I understand your question.
Are you saying you are a descendant of a male from the Valentine Mayo line who was married to a Mayo woman out of William Mayo, the surveyor's line? And you know of a cousin from each line who was known to have shared a home?
Can you tell us who those cousins are and could it be that they just hooked up as Mayo's often tended to mary other Mayos, or it could be as you suspect as I think Valentine and William were first cousins; Valentine out of John and William out of William Sr. (brothers) out of Tristram Mayo who migrated to VA with wife Margaret Wise about 1637. From Shaftsbury England and died in the Tidewater area of VA in 1687. Hopefully the DNA could prove a close connection, but I understand that a marker only mutates on average every 500 years. So, that wouldn't narrow it down to colonial times. It would only say that Mayos are related in England which we already know because our progenitor was Mayeux who was at the battle of Hastings with William the conqueror.
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