You may already have this information but I hope it might help. I have a copy of Cemeteries and Obituaries of Houston County, Georgia by Addie Paramore Howell. After reading your listing I looked in it for Holts. In the section of obituaries of Houston County abstracted from the Georgia Journal & Messenger and the Houston Home Journal were these Holts: Clarence L, Dr Fowler, J T, Lillian Henderson, Lily, Lyndon Patrick, Mattie, Patrick, Col Pulaski, and William H.
For Dr Fowler Holt it only says "Dr Fowler Holt, in the 50th year of his age, died in Perry, Houston Co, GA on Apr 18, 1855". If you would like me to look up any of these other name I will. Just contact me by email.
My ancestor from Houston Co is James Parrish. If you happen across the Parrish name in your Houston research I would be interested. I am at a brick wall with this ancestor.