Re: double mutation
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In reply to:
Re: double mutation
james pace 12/21/09
For single copy markers, the mechanism would be the same as for single mutations, namely slipped strand mispairing illustrated here:
http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=hmg&part=A1049&rendertype=figure&id=A1097http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=hmg&part=A1049&rendertype=figure&id=A1097
The bubble could contain more than one copy of the repeat for multiple insertions or deletions or, probably less likely, there could be more than one bubble.
For multi-copy markers (those labeled a, b, c, etc.), another mechanism, called a conversion (or recLoh), is possible. It is suspected when there is a multi-step mutation and a doubling of one marker. For example, in your case, if one branch were (12,14) on 385 and the other (12, 12) or (14,14), a conversion is another possible explanation. See:
http://www.dna-fingerprint.com/modules.php?op=modload&name=Sections&file=index&req=viewarticle&artid=9http://www.dna-fingerprint.com/modules.php?op=modload&name=Sections&file=index&req=viewarticle&artid=9
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Re: double mutation
james pace 12/22/09