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mtDNA T2 - no HVR2 263G mutation
Posted by: Marian Franklin (ID *****9774) Date: June 24, 2009 at 18:53:44
  of 4712

I'm looking at the genealogies of 20 people. We are all
HVR1: 16126C 16294T 16296T 16304C 16519C (one person may lack 16296T)
HVR2: 73G 309.1C 315.1C (2 people lack 309.1C)

I had noticed that the absence of HVR2 263G was unusual among the T2's when I was searching the various mtDNA databases for exact matches. Ann Turner commented in a DNA-Cousins-L post that most people had the 263G mutation so I went to the British Isles Project (1400+ mtDNA results but not all of them had both HVR1 & 2 results) Except for a few people in Haplogroup H, all the people in all haplogroups , including T, had the 263G mutation. I added my haplotype so now there is one T2 which lacks it. Is it true that there is no way to tell if this is a back mutation to the CRS or no mutation?

The person who may lack the HVR1 16296T was listed by FTDNA
as an exact match. Apparently, from Dr. David Pike's 2006 paper and a comment by Ann Turner on this board, this marker is unstable. One of our direct maternal ancestors was born in Welshpool, Montg., Wales 1816 (Elizabeth Evans) and the other was born in Wales and married a William Evans 'of Welshpool'. There is some hope here of finding a paper trail which connects the two women.

The two people who are 309CRS both had the whole mtDNA sequence and are T2b. Ann Turner wrote recently on this board "Variations in the number of insertions at 309 (recorded as 309.1C, 309.2C etc.) or 16193 (16193.1C, 16193.2C etc.) are very common, with even siblings showing differences. I included these people because one of them had a possible connection to an ancestor of a person who has the 309.1 insertion. The two families lived in the same South Carolina county and had the surname, Moss, in common.



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